Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.1,2,3 Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy.2 It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G1 phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days.1 Quercetin (30 µM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-α, IL-1β, IL-6, and IL-8 induced by PMACI in HMC-1 cells.3
1.Calgarotto, A.K., Maso, V., Junior, G.C.F., et al.Antitumor activities of quercetin and green tea in xenografts of human leukemia HL60 cellsSci. Rep.8(1)3459(2018) 2.Yuan, Y., Ma, S., Qi, Y., et al.Quercetin inhibited cadmium-induced autophagy in the mouse kidney via inhibition of oxidative stressJ. Toxicol. Pathol.29(4)247-252(2016) 3.Park, H.H., Lee, S., Son, H.Y., et al.Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cellsArch. Pharm. Res.31(10)1303-1311(2008)