Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation[1][2][3][4].
Propionyl-DL-carnitine chloride shows protection to beta-thalassaemic erythrocytes from oxidative stress[1].
Propionyl-DL-carnitine chloride increases production of 14CO2 from [1-14C]pyruvate and increases the rate of formation of acetyl camitine from pyruvate[2].
Propionyl-DL-carnitine chloride allows the endothelial cells to maintain their functionality and regulatory role on vessel activity for a longer time and decreases the formation of oxygen reactive species due to xanthine oxidase activity on poxanthine formed by adenine nucleotide catabolism[4].
Propionyl-DL-carnitine chloride (2 mM/kg; p.o. once daily for 4 weeks) affects plasma and urine total carnitine concentrations of mice[3].
| Animal Model: | Adult age-matched male C57BL/6 mice[3] |
| Dosage: | 2 mM/kg |
| Administration: | Oral gavage; 2 mM/kg/day for 4 weeks |
| Result: | Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice. |
[1]. Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9.
[2]. Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biops Res Commun. 1994 Mar 15;199(2):949-53.
[3]. Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and psical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25.
[4]. Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during poxia. Int J Tissue React. 1991;13(1):37-40.