Propacetamol is a prodrug form of the analgesic and antipyretic agent acetaminophen .1 It is converted to acetaminophen by rat liver microsomes. Propacetamol reduces acetic acid-induced writhing in mice and LPS-induced pyresis in rats when administered at doses of 200 and 600 mg/kg, respectively.1,2 Propacetamol (1,200 mg/kg) induces hepatotoxicity, decreases hepatic glutathione (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPX) levels, increases hepatic malondialdehyde (MDA) and nitrotyrosine levels, and increases mortality in mice.3
1.Murie, V.E., Marques, L.M.M., Souza, G.E.P., et al.Acetaminophen prodrug: Microwave-assisted synthesis and in vitro metabolism evaluation by mass spectrometryJ. Braz. Chem. Soc.27(6)1121-1128(2016) 2.Zhang , Y., Du, L., Pan, H., et al.Enhanced analgesic effects of propacetamol and tramadol combination in rats and miceBiol. Pharm. Bull.34(3)349-353(2011) 3.Liou, G.-G., Hsieh, C.-C., Lee, Y.-J., et al.N-Acetyl cysteine overdose inducing hepatic steatosis and systemic inflammation in both propacetamol-induced hepatotoxic and normal miceAntioxidants (Basel)10(3)442(2021)