Proadrenomedullin (45-92) (human) (trifluoroacetate salt)

Proadrenomedullin (45-92) (MR-proADM) is a peptide that is comprised of amino acid residues 45-92 of preproadrenomedullin.¹ MR-proADM has no effect on precontracted isolated cat pulmonary arterial rings when used at concentrations up to 10 μM, unlike adrenomedullin (1-52) and adrenotensin, which induce relaxation and contraction, respectively.² Levels of MR-proADM are elevated in the plasma of patients with sepsis and those with cardiovascular disease and positively correlate with disease severity in patients with community-acquired pneumonia.^1,3