Poliumoside is a caffeoylated phenylpropanoid glycoside [1]. Poliumoside inhibits the formation of advanced glycation end products (AGEs, IC₅₀ = 19.69μM) and rat lens aldose reductase (RLAR, IC₅₀ = 8.47μM) [2]. Poliumoside has antioxidant and cell aggregation inhibitory effects [3-4].
In bone mesenchymal stem cells, Poliumoside (75μM, 150μM, 225μM, 300μM, 375μM; 24h) inhibits HGHF-induced BMSC ferroptosis [5]. In A549 cells, Poliumoside (10μM, 20μM, 40μM; 24h) alleviates TNF-α-induced cell damage by simultaneously regulating the NF-κB pathway and the Nrf2 pathway [6].
In Transient middle cerebral artery occlusion mouse model, Poliumoside (5mg/kg, 10mg/kg, 15mg/kg; ip; 3d) improves neurological function and reduces infarct volume after stroke [7]. In the cognitive dysfunction rat model, Poliumoside (5mg/kg, 10mg/kg; ip; 21d) treatment improved cognitive capacity in rats in morris water maze and recognition tests [8].
References:
[1]. He ZD, Lau KM, Xu HX, et al. Antioxidant activity of phenylethanoid glycosides from Brandisia hancei. Journal of ethnopharmacology. 2000 Aug 1; 71(3): 483-486.
[2]. Yu SY, Lee IS, Jung SH, et al. Caffeoylated phenylpropanoid glycosides from Brandisia hancei inhibit advanced glycation end product formation and aldose reductase in vitro and vessel dilation in larval zebrafish in vivo. Planta medica. 2013 Dec; 79(18): 1705-1709.
[3]. De Marino S, Festa C, Zollo F, et al. Antioxidant activity of phenolic and phenylethanoid glycosides from Teucrium polium L. Food Chemistry. 2012 Jul 1;133(1): 21-28.
[4]. Tatli II, Takamatsu S, Khan I, et al. Screening for free radical scavenging and cell aggregation inhibitory activities by secondary metabolites from Turkish Verbascum species [J]. Zeitschrift für Naturforschung C. 2007 Oct 1; 62(9-10): 673-678.
[5]. Xu CY, Xu C, Xu YN, et al. Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway. Phytomedicine. 2024 Mar 1; 125: 155342.
[6]. Zheng JN, Zhuo JY, Nie J, et al. Phenylethanoid glycosides from Callicarpa kwangtungensis Chun attenuate TNF-α-induced cell damage by inhibiting NF-κB pathway and enhancing Nrf2 pathway in A549 cells. Frontiers in pharmacology. 2021 Jul 7; 12: 693983.
[7]. Gao Y, Wang J, Zhang C, et al. Poliumoside alleviates microglia-mediated inflammation and blood-brain barrier disruption via modulating the polarization of microglia after ischemic stroke in mice. Phytomedicine. 2025 May 23: 156881.
[8]. Zuo Y, Chen B, Li X, et al. Poliumoside inhibits apoptosis, oxidative stress and neuro-inflammation to prevent intracerebroventricular Streptozotocin-induced cognitive dysfunction in Sprague-Dawley Rats: in in-vivo, in-vitro and in-silico study. Folia Morphologica. 2024 Oct 23.
Poliumoside是一种咖啡酰化的苯丙烷类糖苷 [1]。Poliumoside可抑制晚期糖基化终产物（AGEs，IC₅₀ = 19.69μM）和大鼠晶状体醛糖还原酶（RLAR，IC₅₀ = 8.47μM）的形成 [2]。Poliumoside具有抗氧化和抑制细胞聚集的作用 [3-4]。
在骨髓间充质干细胞中，Poliumoside（75μM、150μM、225μM、300μM、375μM；24h）可抑制人生长因子受体（HGHF）诱导的骨髓间充质干细胞（BMSC）铁死亡 [5]。在A549细胞中，Poliumoside（10μM、20μM、40μM；24h）通过同时调控NF-κB通路和Nrf2通路，减轻TNF-α诱导的细胞损伤 [6]。
在小鼠短暂性大脑中动脉闭塞模型中，Poliumoside（5mg/kg、10mg/kg、15mg/kg；ip；3d）可改善中风后的神经功能，减少梗死体积 [7]。在大鼠认知功能障碍的模型中，Poliumoside（5mg/kg、10mg/kg；ip；21d）治疗可改善大鼠在Morris水迷宫和识别测试中的认知能力 [8]。