GlpBio

PKG Inhibitor (trifluoroacetate salt)

目录号: GC92078纯度: >95.00%同义词: Arginyl-<wbr>lysyl-<wbr>arginyl-<wbr>alanyl-<wbr>arginyl-<wbr>lysyl-<wbr>glutamic acid; Protein Kinase G Inhibitor
PKG Inhibitor (trifluoroacetate salt)是一种特定的cGMP依赖性PKG抑制剂Ki=86μM。
PKG Inhibitor (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥798.00现货
1
5 mg¥3,668.00现货
1
10 mg¥6,538.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 μM).1 This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.1 PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.2

References:
[1]. Glass, D.B.Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitorsBiochem. J.213(1)159-164(1983).
[2]. Wexler, E.M., Stanton, P.K., and Nawy, S.Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesteraseJ. Neurosci.18(7)2342-2349(1998).

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

同义词
Arginyl-<wbr>lysyl-<wbr>arginyl-<wbr>alanyl-<wbr>arginyl-<wbr>lysyl-<wbr>glutamic acid; Protein Kinase G Inhibitor
化学名
L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid, trifluoroacetate salt
SMILES
O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCCN)N[C@@H](CCC(O)=O)C(O)=O.FC(F)(F)C(O)=O
分子式
C38H74N18O10 ? XCF3COOH
分子量
943.1 g/mol
溶解性
DMF: 5 mg/ml,DMSO: 15 mg/ml,PBS (pH 7.2): 10 mg/ml
保存条件
-20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol