Amyloid β protein

Amyloid β protein(β淀粉样蛋白)

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.

The normal function of Aβ is not well understood. Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, several potential activities have been discovered for Aβ, including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, functioning as a transcription factor, and anti-microbial activity (potentially associated with Aβ's pro-inflammatory activity).

The glymphatic system clears metabolic waste from the mammalian brain, and in particular amyloid beta. Indeed, a number of proteases have been implicated by both genetic and biochemical studies as being responsible for the recognition and degradation of amyloid beta; these include insulin degrading enzyme.and presequence protease. The rate of removal is significantly increased during sleep. However, the significance of the lymphatic system in Aβ clearance in Alzheimer's disease is unknown.

Amyloid β protein 相关产品(164)

GA21424 ent-Amyloid β-Protein (1-42)
CAS: 342896-25-7
All-D Aβ (1-42) exhibits similar properites as the all-L Aβ. The peptide forms ion channels in lipid bilayers.
GA21460 FITC-β-Ala-Amyloid β-Protein (1-40)
CAS: 1802087-76-8
GA21461 FITC-β-Ala-Amyloid β-Protein (1-42)
CAS: 1802087-77-9
GA21462 FITC-εAhx-Amyloid β-Protein (1-42)
GA23171 Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675)-Lys(Dnp)
CAS: 1802078-31-4
Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF.
GA23175 Mca-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide
CAS: 1802078-33-6
This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.
GA23270 N-Me-Abz-Amyloid β/A4 Protein Precursor₇₇₀ (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide
CAS: 600728-90-3
Intramolecularly quenched fluorescent, presenilin-dependent substrate for assaying γ-secretase activity. The FRET substrate has been used for partial purification and characterization of γ-secretase from post-mortem human brain.
GA23600 Teplow's Amyloid β-Protein (1-40) (scrambled II)
CAS: 1987844-71-2
This peptide is a specifically designed negative control in studies with Abeta40. It is "scrambled", which means it contains the same amino acids as Abeta40, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-40) does not show a number of phenomena regularly observed with Abeta40 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
GA23601 Teplow's Amyloid β-Protein (1-42) (scrambled II)
CAS: 1987844-92-7
This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
GA23614 Tide Fluor™ 5WS-Amyloid β-Protein (1-40)
Fluorescent dye-labeled Aβ40, excitation at 649 nm, emission at 664 nm. Tide Fluor™ 5WS shows strong fluorescence and excellent photostability.
GA23616 Tide Fluor™ 7WS-Amyloid β-Protein (1-40)
Fluorescent dye-labeled Aβ40, excitation at 749nm, emission at 775nm. Tide Fluor™ 7WS shows strong fluorescence and excellent photostability.
GC16243 β-Amyloid (1-42), human TFA
CAS: 107761-42-2
纯度: >98.00% / >99.00%
β-Amyloid (1-42), human TFA淀粉样蛋白 β 肽 (1-42) 人 TFA 是一种由 42 个氨基酸组成的肽。
GC30325 β-Amyloid 22-35 (Amyloid β-Protein (22-35))
CAS: 144189-71-9
β-Amyloid 22-35 (Amyloid β-Protein (22-35))是一种由14个氨基酸组成的多肽片段，能够自发聚集形成β-折叠结构，并对海马神经元产生显著的细胞毒性作用。
GC31129 β-Amyloid 1-16 (Amyloid β-Protein (1-16))
CAS: 131580-10-4
纯度: >98.50%
β-Amyloid 1-16 (Amyloid β-Protein (1-16)) 是 ⋲-Amyloid 蛋白片段，参与金属结合。
GC31137 β-Amyloid 29-40 (Amyloid beta-protein(29-40))
CAS: 184865-04-1
β-Amyloid 29-40 (Amyloid beta-protein(29-40)) 是 Amyloid-β 的一个片段；肽。
GC31146 β-Amyloid (10-35), amide
CAS: 181427-66-7
β-Amyloid(10-35),amide是一种含有26个氨基酸的多肽，由β-Amyloid肽的10-35残基组成。β-Amyloid(10-35)是阿尔兹海默症淀粉样斑块(Alzheimer'sdisease)的主要组成成分。
GC31171 β-Amyloid 1-28 (Amyloid β-Protein (1-28))
CAS: 109770-29-8
β-Amyloid 1-28 (Amyloid β-Protein (1-28)) 是 β-Amyloid 蛋白片段，参与金属结合。
GC31179 β-Amyloid 31-35
CAS: 149385-65-9
纯度: >99.50%
β-Amyloid(31-35)是具有神经毒性的天然β淀粉样肽的最短序列。
GC34232 Beta-Amyloid(1-14),mouse,rat
Beta-Amyloid(1-14),mouse,rat是Amyloid-β多肽的1-14片段。
GC34242 β-Amyloid (1-42), rat TFA
β-Amyloid(1-42),ratTFA是由42个氨基酸组成的多肽，对海马切片有毒性，可用于阿尔兹海默症的研究。
GC34391 β-Amyloid 15-21 (Beta-Amyloid (15-21))
β-amyloid(15-21)是β淀粉样肽的一个片段，在神经领域具有潜在的作用。
GC35334 Amyloid β Peptide (42-1)(human)
CAS: 317366-82-8
淀粉样蛋白 β Peptide (42-1)(human) 是淀粉样蛋白 β 的无活性形式；肽 (1-42)。
GC35335 Amyloid β-peptide (1-40) rat
CAS: 144409-98-3
淀粉样蛋白 ⋲-肽 (1-40) 大鼠是淀粉样蛋白 β-肽的大鼠形式，它作为不溶性细胞外沉积物积聚在神经元周围，导致与阿尔茨海默病 (AD) 相关的老年斑。
GC37984 β-Amyloid (1-42), rat
CAS: 166090-74-0
纯度: >95.00%
β-Amyloid (1-42), rat 是一种 42-aa 肽，对急性海马切片有细胞毒作用，用于研究老年痴呆症's disease。

分类产品列表
货号	产品名称	CAS号	纯度
GA21424	ent-Amyloid β-Protein (1-42)	342896-25-7	-
GA21424	All-D Aβ (1-42) exhibits similar properites as the all-L Aβ. The peptide forms ion channels in lipid bilayers.
GA21460	FITC-β-Ala-Amyloid β-Protein (1-40)	1802087-76-8	-
GA21461	FITC-β-Ala-Amyloid β-Protein (1-42)	1802087-77-9	-
GA21462	FITC-εAhx-Amyloid β-Protein (1-42)	-	-
GA23171	Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675)-Lys(Dnp)	1802078-31-4	-
GA23171	Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF.
GA23175	Mca-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide	1802078-33-6	-
GA23175	This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.
GA23270	N-Me-Abz-Amyloid β/A4 Protein Precursor₇₇₀ (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide	600728-90-3	-
GA23270	Intramolecularly quenched fluorescent, presenilin-dependent substrate for assaying γ-secretase activity. The FRET substrate has been used for partial purification and characterization of γ-secretase from post-mortem human brain.
GA23600	Teplow's Amyloid β-Protein (1-40) (scrambled II)	1987844-71-2	-
GA23600	This peptide is a specifically designed negative control in studies with Abeta40. It is "scrambled", which means it contains the same amino acids as Abeta40, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-40) does not show a number of phenomena regularly observed with Abeta40 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
GA23601	Teplow's Amyloid β-Protein (1-42) (scrambled II)	1987844-92-7	-
GA23601	This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
GA23614	Tide Fluor™ 5WS-Amyloid β-Protein (1-40)	-	-
GA23614	Fluorescent dye-labeled Aβ40, excitation at 649 nm, emission at 664 nm. Tide Fluor™ 5WS shows strong fluorescence and excellent photostability.
GA23616	Tide Fluor™ 7WS-Amyloid β-Protein (1-40)	-	-
GA23616	Fluorescent dye-labeled Aβ40, excitation at 749nm, emission at 775nm. Tide Fluor™ 7WS shows strong fluorescence and excellent photostability.
GC16243	β-Amyloid (1-42), human TFA	107761-42-2	>98.00% / >99.00%
GC16243	β-Amyloid (1-42), human TFA淀粉样蛋白 β 肽 (1-42) 人 TFA 是一种由 42 个氨基酸组成的肽。
GC30325	β-Amyloid 22-35 (Amyloid β-Protein (22-35))	144189-71-9	-
GC30325	β-Amyloid 22-35 (Amyloid β-Protein (22-35))是一种由14个氨基酸组成的多肽片段，能够自发聚集形成β-折叠结构，并对海马神经元产生显著的细胞毒性作用。
GC31129	β-Amyloid 1-16 (Amyloid β-Protein (1-16))	131580-10-4	>98.50%
GC31129	β-Amyloid 1-16 (Amyloid β-Protein (1-16)) 是 ⋲-Amyloid 蛋白片段，参与金属结合。
GC31137	β-Amyloid 29-40 (Amyloid beta-protein(29-40))	184865-04-1	-
GC31137	β-Amyloid 29-40 (Amyloid beta-protein(29-40)) 是 Amyloid-β 的一个片段；肽。
GC31146	β-Amyloid (10-35), amide	181427-66-7	-
GC31146	β-Amyloid(10-35),amide是一种含有26个氨基酸的多肽，由β-Amyloid肽的10-35残基组成。β-Amyloid(10-35)是阿尔兹海默症淀粉样斑块(Alzheimer'sdisease)的主要组成成分。
GC31171	β-Amyloid 1-28 (Amyloid β-Protein (1-28))	109770-29-8	-
GC31171	β-Amyloid 1-28 (Amyloid β-Protein (1-28)) 是 β-Amyloid 蛋白片段，参与金属结合。
GC31179	β-Amyloid 31-35	149385-65-9	>99.50%
GC31179	β-Amyloid(31-35)是具有神经毒性的天然β淀粉样肽的最短序列。
GC34232	Beta-Amyloid(1-14),mouse,rat	-	-
GC34232	Beta-Amyloid(1-14),mouse,rat是Amyloid-β多肽的1-14片段。
GC34242	β-Amyloid (1-42), rat TFA	-	-
GC34242	β-Amyloid(1-42),ratTFA是由42个氨基酸组成的多肽，对海马切片有毒性，可用于阿尔兹海默症的研究。
GC34391	β-Amyloid 15-21 (Beta-Amyloid (15-21))	-	-
GC34391	β-amyloid(15-21)是β淀粉样肽的一个片段，在神经领域具有潜在的作用。
GC35334	Amyloid β Peptide (42-1)(human)	317366-82-8	-
GC35334	淀粉样蛋白 β Peptide (42-1)(human) 是淀粉样蛋白 β 的无活性形式；肽 (1-42)。
GC35335	Amyloid β-peptide (1-40) rat	144409-98-3	-
GC35335	淀粉样蛋白 ⋲-肽 (1-40) 大鼠是淀粉样蛋白 β-肽的大鼠形式，它作为不溶性细胞外沉积物积聚在神经元周围，导致与阿尔茨海默病 (AD) 相关的老年斑。
GC37984	β-Amyloid (1-42), rat	166090-74-0	>95.00%
GC37984	β-Amyloid (1-42), rat 是一种 42-aa 肽，对急性海马切片有细胞毒作用，用于研究老年痴呆症's disease。