Amyloid β protein
Amyloid β protein(β淀粉样蛋白)
Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
The normal function of Aβ is not well understood. Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, several potential activities have been discovered for Aβ, including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, functioning as a transcription factor, and anti-microbial activity (potentially associated with Aβ's pro-inflammatory activity).
The glymphatic system clears metabolic waste from the mammalian brain, and in particular amyloid beta. Indeed, a number of proteases have been implicated by both genetic and biochemical studies as being responsible for the recognition and degradation of amyloid beta; these include insulin degrading enzyme.and presequence protease. The rate of removal is significantly increased during sleep. However, the significance of the lymphatic system in Aβ clearance in Alzheimer's disease is unknown.
Amyloid β protein 相关产品(164)
- GA20742Amyloid β-Protein (17-40)CAS: 156790-69-1
Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.
- GA20744Amyloid β-Protein (2-42)CAS: 1678416-22-2
Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages.
- GA20745Amyloid β-Protein (25-35) amideCAS: 147490-49-1纯度: >98.00%
Amyloid β-Protein (25-35) amide是β淀粉样蛋白（amyloid-β，Aβ）酰胺化的一种产物，其中β淀粉样蛋白的生成能力已被强烈降低。
- GA20746Amyloid β-Protein (33-42)CAS: 178949-81-0纯度: >98.00%
GLMVGGVVIA, a partial sequence of β-amyloid protein which is used for raising antibodies against Aβ 1-42. Li et al. studied the aggregation behavior of this and other Aβ 1-42 C-terminal fragments.
- GA20748Amyloid β-Protein (3-42)CAS: 157884-74-7
The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate.
- GA20754Amyloid β-Protein (4-42)CAS: 157884-72-5
Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases.
- GA20755Amyloid β-Protein (5-42)CAS: 1678415-97-8
Abeta 5-42 is produced from amyloid precursor protein by action of caspases. It is deposited in Alzheimer's disease brain as well, but less prone to aggregation.
- GA20780Arg-Glu(EDANS)-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (668-675)-Lys(DABCYL)-ArgCAS: 310427-94-2
Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min?¹.
- GA20823Biotinyl-Amyloid β-Protein (1-40)CAS: 183906-14-1
Biotinyl-Amyloid β-Protein (1-40) 是一种 N 端标记的生物素化淀粉样蛋白 ß-(1-40) 肽。
- GA20854Biotinyl-εAhx-Amyloid β-Protein (1-40)CAS: 1802086-72-1
The flexible LC spacer increases the accessibility of the biotin moiety.
- GA20855Biotinyl-εAhx-Amyloid β-Protein (1-42)
The flexible LC spacer increases the accessibility of the biotin moiety.
- GA21423ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])CAS: 1426174-31-3
This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 . 10?² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM). It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GA20741 | Amyloid β-Protein (16-22) | 153247-41-7 | - | |
Self-assembling Aβ sequence. | ||||
| GA20742 | Amyloid β-Protein (17-40) | 156790-69-1 | - | |
Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome. | ||||
| GA20743 | Amyloid β-Protein (20-29) | 311818-43-6 | - | |
FAEDVGSNKG. | ||||
| GA20744 | Amyloid β-Protein (2-42) | 1678416-22-2 | - | |
Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages. | ||||
| GA20745 | Amyloid β-Protein (25-35) amide | 147490-49-1 | >98.00% | |
Amyloid β-Protein (25-35) amide是β淀粉样蛋白（amyloid-β，Aβ）酰胺化的一种产物，其中β淀粉样蛋白的生成能力已被强烈降低。 | ||||
| GA20746 | Amyloid β-Protein (33-42) | 178949-81-0 | >98.00% | |
GLMVGGVVIA, a partial sequence of β-amyloid protein which is used for raising antibodies against Aβ 1-42. Li et al. studied the aggregation behavior of this and other Aβ 1-42 C-terminal fragments. | ||||
| GA20747 | Amyloid β-Protein (3-40) | 157884-70-3 | - | |
| GA20748 | Amyloid β-Protein (3-42) | 157884-74-7 | - | |
The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate. | ||||
| GA20749 | Amyloid β-Protein (35-25) | 147740-73-6 | - | |
Aβ 25-35 的反向序列，非活性对照。 | ||||
| GA20750 | Amyloid β-Protein (36-38) | 21835-35-8 | - | |
| GA20751 | Amyloid β-Protein (37-39) | 20274-89-9 | - | |
| GA20752 | Amyloid β-Protein (40-1) | 144409-99-4 | - | |
Reverse sequence of Aβ 1-40. | ||||
| GA20754 | Amyloid β-Protein (4-42) | 157884-72-5 | - | |
Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases. | ||||
| GA20755 | Amyloid β-Protein (5-42) | 1678415-97-8 | - | |
Abeta 5-42 is produced from amyloid precursor protein by action of caspases. It is deposited in Alzheimer's disease brain as well, but less prone to aggregation. | ||||
| GA20756 | Amyloid β-Protein (6-20) | 183745-82-6 | - | |
| GA20780 | Arg-Glu(EDANS)-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (668-675)-Lys(DABCYL)-Arg | 310427-94-2 | - | |
Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min?¹. | ||||
| GA20823 | Biotinyl-Amyloid β-Protein (1-40) | 183906-14-1 | - | |
Biotinyl-Amyloid β-Protein (1-40) 是一种 N 端标记的生物素化淀粉样蛋白 ß-(1-40) 肽。 | ||||
| GA20824 | Biotinyl-Amyloid β-Protein (1-42) | 1802086-20-9 | - | |
N-terminally biotin-labeled Aβ42. | ||||
| GA20854 | Biotinyl-εAhx-Amyloid β-Protein (1-40) | 1802086-72-1 | - | |
The flexible LC spacer increases the accessibility of the biotin moiety. | ||||
| GA20855 | Biotinyl-εAhx-Amyloid β-Protein (1-42) | - | - | |
The flexible LC spacer increases the accessibility of the biotin moiety. | ||||
| GA21351 | Cys-Gly-His-Gly-Asn-Lys-Ser-Amyloid β-Protein (33-40) | 1802078-22-3 | - | |
CGHGNKSGLMVGGVV. | ||||
| GA21352 | Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) | 1802086-21-0 | - | |
| GA21353 | Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (35-40) | 1802078-24-5 | - | |
| GA21423 | ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]) | 1426174-31-3 | - | |
This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 . 10?² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM). It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures. | ||||