GlpBio

Pep19-2.5

目录号: GC72191纯度: >98.00%
Pep19-2.5是一种合成的抗毒素肽，阻断细胞内内毒素信号级联。
Pep19-2.5
Cas No.: 1322711-38-5
规格价格库存数量操作
1 mg¥540.00现货
1
5 mg¥1,440.00现货
1
10 mg¥2,340.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis.

Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded with Ceftriaxone (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit[2].

References:
[1]. Heinbockel L, et al. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5. Front Immunol. 2018 Jul 26;9:1704.
[2]. Bárcena-Varela S, et al. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Exp Mol Med. 2017 Jun 16;49(6):e345.
[3]. Jannadi H, et al. Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation. Microb Pathog. 2019 Aug;133:103546.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1322711-38-5
分子式
C135H187N37O22S
分子量
2712.23 g/mol
保存条件
Sealed storage, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol