PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.
PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1].
PE 22-28 (i.p.; 3.0µg/kg) shows antidepressant property[1].
References:
[1]. Alaeddine Djillani, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017 Sep 12;8:643.