PD1-PDL1-IN 1 TFA is a potent programmed cell death 1 (PD-1) inhibitor that is useful as immune modulator [1]. PD1-PDL1-IN 1 TFA can impede PD-1 signal transduction during co-culture experiments by disrupting protein interactions between PD-1 and PD-L1, and exhibits synergy when paired with PD-1/PD-L1 inhibitors, particularly when targeting the epigenetic or metabolic pathways of specific immune cells [2].
References:
[1] Pottayil Govindan Nair Sasikumar, et al. 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators. WO2016142886A2.
[2] Parvez A, Choudhary F, Mudgal P, et al. PD-1 and PD-L1: architects of immune symphony and immunotherapy breakthroughs in cancer treatment[J]. Frontiers in immunology, 2023, 14: 1296341.
PD1-PDL1-IN 1 TFA是一种强效的程序性死亡受体1（PD-1）抑制剂，可用作免疫调节剂[1]。PD1-PDL1-IN 1 TFA通过在共培养实验中破坏PD-1与PD-L1之间的蛋白质相互作用，阻碍PD-1信号转导，并且在与PD-1/PD-L1抑制剂（尤其是靶向特定免疫细胞的表观遗传或代谢通路时）联合使用时表现出协同作用[2]。