PD 90780 is an inhibitor of the interaction between NGF and the p75 NGF receptor (NGFR).1 It binds to NGF (KD = 25.83 μM) and inhibits NGF binding to the extracellular domain of p75 NGFR (IC50 = 220 nM), as well as to Q1-CHO cells expressing full-length human p75 NGFR (IC50 = 300 nM).1,2 PD 90780 inhibits NGF-dependent differentiation of PC12 cells (IC50 = 33.22 μM).2
1.Spiegel, K., Agrafiotis, D., Caprathe, B., et al.PD 90780, a non peptide inhibitor of nerve growth factor's binding to the P75 NGF receptorBiochem. Biophys. Res. Commun.217(2)488-494(1995) 2.Kennedy, A.E., Laamanen, C.A., Ross, M.S., et al.Nerve growth factor inhibitor with novel-binding domain demonstrates nanomolar efficacy in both cell-based and cell-free assay systemsPharmacol. Res. Perspect.5(5)e00339(2017)