Pro-xylane是一种源自山毛榉木糖的、具有生物活性的C-糖苷。
Cas No.:439685-79-7
Sample solution is provided at 25 µL, 10mM.
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Pro-xylane is a bioactive C-glycoside derived from Fagus sylvatica xylose. Pro-xylane stimulates the synthesis of glycosaminoglycans (GAGs) and hyaluronic acid to fill the extracellular matrix and lock in moisture, while strengthening the dermo-epidermal junction by promoting the synthesis of type IV and VII collagens. Pro-xylane can be used in studies related to skin anti-aging and chronic wound healing[1-4].
In vitro, epidermal keratinocytes and dermal fibroblasts were treated with Pro-xylane (1–3mM) for 48 hours. Pro-xylane significantly induced filaggrin expression and promoted α-smooth muscle actin generation, while inhibiting the secretion of the inflammatory factor prostaglandin E2[5]. Pro-xylane (0.3–3mM) was applied to dermal fibroblasts for 72 hours. Pro-xylane significantly stimulated the synthesis of sulfated glycosaminoglycans (GAGs)[6].
References:
[1] Dou Z, Hu PR, Song LL, et al. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose. Int J Biol Macromol. 2025 May;305(Pt 2):140976. doi: 10.1016/j.ijbiomac.2025.140976.
[2] Zhao Y, Li Y, Shang J, et al. Engineering a Carbonyl Reductase for High-Efficiency Synthesis of Optically Pure (S)-Pro-Xylane: An Alternative Synthetic Route. J Agric Food Chem. 2025 Apr 23;73(16):9759-9768.
[3] Jiang X, Peng S, Chen Y, et al. A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging. J Cosmet Dermatol. 2025 Jul;24(7):e70281.
[4] Zang S, Chen J, Chevalier C, et al. Holistic investigation of the anti-wrinkle and repair efficacy of a facial cream enriched with C-xyloside. J Cosmet Dermatol. 2024 Dec;23(12):4017-4028.
[5] Ablon G, Paturi J, Juchaux F, et al. The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study. J Clin Aesthet Dermatol. 2025 Dec;18(12):66-72.
[6] Cavezza A, Boulle C, Guéguiniat A, et al. Synthesis of Pro-Xylane: a new biologically active C-glycoside in aqueous media. Bioorg Med Chem Lett. 2009 Feb 1;19(3):845-9.
Pro-xylane是一种源自山毛榉木糖的、具有生物活性的C-糖苷。Pro-xylane可刺激糖胺聚糖（GAGs）和透明质酸的合成来填充细胞外基质并锁水保湿，同时通过促进IV型和VII型胶原蛋白合成以强化真皮-表皮连接。Pro-xylane 可用于皮肤抗衰老和慢性伤口愈合的相关研究[1-4]。
在体外，Pro-xylane（1–3mM）处理表皮角质形成细胞及真皮成纤维细胞48小时。Pro-xylane显著诱导丝聚蛋白表达并促进α-平滑肌肌动蛋白生成，同时抑制炎症因子前列腺素E2的分泌[5]。Pro-xylane（0.3–3mM）处理真皮成纤维细胞72小时。Pro-xylane显著刺激硫酸化糖胺聚糖（GAGs）的合成[6]。
| Cell experiment [1]: | |
Cell lines | Human dermal fibroblasts (normal human dermal fibroblast, NHDF) |
Preparation Method | Normal human dermal fibroblast (NHDF) monolayers were cultured in control medium with or without Pro-xylane at the indicated concentrations for 72h at 37°C in humid atmosphere of 95% air and 5% CO₂, and labeled with ³⁵S-sulfur during the final 24h. |
Reaction Conditions | 0.3mM-3.0mM; 72h |
Applications | Pro-xylane significantly stimulated the biosynthesis of sulfated glycosaminoglycans (GAGs) by human fibroblasts in a dose-dependent manner, as evidenced by the increased incorporation of ³⁵S-radioactivity into the isolated GAG fraction. |
References: | |
| Cas No. | 439685-79-7 | SDF | |
| 别名 | 玻色因; Hydroxypropyl tetrahydropyrantriol | ||
| Canonical SMILES | CC(O)C[C@H]1[C@@H]([C@H]([C@H](O)CO1)O)O | ||
| 分子式 | C8H16O5 | 分子量 | 192.21 |
| 溶解度 | Water: 250 mg/mL (1300.66 mM); DMSO: ≥ 83.33 mg/mL (433.54 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2026 mL | 26.0132 mL | 52.0264 mL |
| 5 mM | 1.0405 mL | 5.2026 mL | 10.4053 mL |
| 10 mM | 520.3 μL | 2.6013 mL | 5.2026 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet