PD-1 (programmed cell death 1) protein negatively regulates immune responses and affects processes such as apoptosis and tolerance induction. It is a transmembrane protein found on the outside of the plasma membrane and expressed in the retina. PD-1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag.
PD-1 Protein, Mouse (HEK293, His-Fc)
目录号: GC26686纯度: >98%
PD-1（程序性细胞死亡 1）蛋白负向调节免疫反应并影响细胞凋亡和耐受诱导等过程。
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5ug | ¥630.00 | 现货 | 1 | |
| 10ug | ¥1,071.00 | 现货 | 1 | |
| 50ug | ¥2,988.00 | 现货 | 1 | |
| 100ug | ¥5,085.00 | 现货 | 1 |
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Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
产品描述 Description
产品文档 Product Documents
Purity:>98%
Product Data
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Source
HEK293
Physical Appearance
Lyophilized powder.
Synonyms
Programmed cell death protein 1; PD1; CD279; PDCD1
Amino Acid Sequence
LEVPNGPWRS LTFYPAWLTV SEGANATFTC SLSNWSEDLM LNWNRLSPSN QTEKQAAFCN GLSQPVQDAR FQIIQLPNRH DFHMNILDTR RNDSGIYLCG AISLHPKAKI EESPGAELVV TERILETSTR YPSPSPKPEG RFQ
Apparent Molecular Weight
60-65 kDa Da
Stability
Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Biological Activity
1. Determined by its ability to prevent plate adhesion of PHA-stimulated Jurkat cells in the presence of 625 ng/mL of bound hPD-L1. The ED<sub>50</sub> for this effect is 0.4262 μg/mL, corresponding to a specific activity is 2.35×10<sup>3</sup> units/mg.
2. Immobilized Recombinant Mouse PD-1 at 1 μg/ml (100 μl/well) can bind Recombinant Mouse PD-L1. The ED50 for this effect is 0.5001 μg/mL.
Determined by its ability to prevent plate adhesion of PHA-stimulated Jurkat cells in the presence of 625ng/mL of bound hPD-L1. The ED<sub>50</sub> for this effect is 0.4262 μg/mL, corresponding to a specific activity is 2.35×10<sup>3</sup> units/mg.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 (Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.) or 20 mM PB, 150 mM NaCl, pH 7.4.