PD-1/PD-L1-IN-13

PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC₅₀ value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8⁺ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model^[1].

[1]. Song Z, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluorometleneoxy Linkage. J Med Chem. 2021;64(22):16687-16702.