GlpBio

PBRM1-BD2-IN-5

目录号: GC73351纯度: >99.00%
PBRM1-BD2-IN-5是一种强效的PBRM1溴胺抑制剂，对PBRM1-BD2和PBRM1-BD的Kd值分别为1.5μM和3.9μM，对PBRM 1-BD2的IC50值为0.26μM。
PBRM1-BD2-IN-5
Cas No.: 2819989-61-0
规格价格库存数量操作
1 mg¥1,260.00现货
1
5 mg¥2,592.00现货
1
10 mg¥3,150.00现货
1
25 mg¥4,410.00现货
1
50 mg¥5,310.00现货
1
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文献被引

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer.

PBRM1-BD2-IN-5 (compound 16) (0-10 μM; 5 days) inhibits PBRM1-expressed LNCaP cells, and reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides[1].

References:
[1]. Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
2819989-61-0
分子式
C15H13ClN2O
分子量
272.73 g/mol
溶解性
DMSO : 100 mg/mL (366.66 mM; Need ultrasonic)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol