Palmitic Acid Alkyne is a palmitic acid with an ω-terminal alkyne and a click chemistry reagent acting as an alkyl chain-based PROTAC linker with molecules containing azide groups[1]. Palmitic acid alkyne is applied in protein detection, conjugative traffic binding, imaging assistive vectors, and PROTAC linkers [2,3,4,5].
References:
[1] Honcharenko, Dmytro et al. “New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides.” *ACS omega* vol. 6,1 579-593. 18 Dec. 2020, doi:10.1021/acsomega.0c05075
[2] Yap, Megan C et al. “Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry.” *Journal of lipid research* vol. 51,6 (2010): 1566-80. doi:10.1194/jlr.D002790
[3] García-Cazorla, Yolanda et al. “Conjugation inhibitors compete with palmitic acid for binding to the conjugative traffic ATPase TrwD, providing a mechanism to inhibit bacterial conjugation.” *The Journal of biological chemistry* vol. 293,43 (2018): 16923-16930. doi:10.1074/jbc.RA118.004716
[4] Paiva, Eduardo M, and Florian M Schmidt. “Ultrafast Widefield Mid-Infrared Photothermal Heterodyne Imaging.” *Analytical chemistry* vol. 94,41 (2022): 14242-14250. doi:10.1021/acs.analchem.2c02548
[5] Gao, Xinxin, and Rami N Hannoush. “A Decade of Click Chemistry in Protein Palmitoylation: Impact on Discovery and New Biology.” *Cell chemical biology*vol. 25,3 (2018): 236-246. doi:10.1016/j.chembiol.2017.12.002
Palmitic Acid Alkyne是一种具有ω端炔的棕榈酸，其化学试剂与含有叠氮基团的分子作为烷基链型PROTAC连接剂[1]。棕榈酸炔应用于蛋白质检测、共轭交通结合、成像辅助载体和PROTAC连接物[2,3,4,5]。