The p-Cresol is a protein-bound uremic retention solute 1.
Free p-Cresol was found to be a cardiovascular risk factor in non-diabetic hemodialysis patients. In patients with diabetes, the level of both free p-cresol and total p-cresol were markedly higher. In patients treated by hemodialysis, the levels of these two forms of p-cresol were also significantly higher than that of patients treated by hemodiafiltration. The univariate cox proportional hazard analysis showed that the concentration of free p-cresol was obviously associated with cardiovascular disease (CVD). Quite many patients with high free p-cresol concentrations had new fatal or non-fatal cardiovascular events. Besides that, p-cresol was also found to inhibit cell proliferation. It inhibited the proliferation of cultured endothelial cells by 26% without affecting cell viability. Moreover, p-cresol treatment reduced endothelial wound repair by 19%, 28% and 40% at concentrations of 10, 25 and 50 μg/ml, respectively 1,2.
References:
1.?Meijers B K I, Bammens B, De Moor B, et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney international, 2008, 73(10): 1174-1180.
2.?Dou L, Bertrand E, Cerini C, et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney international, 2004, 65(2): 442-451.
对甲酚是一种与蛋白质结合的尿毒症滞留溶质1。
游离对甲酚被发现是非糖尿病血液透析患者的心血管危险因素。在糖尿病患者中，游离对甲酚和总对甲酚的水平明显更高。在接受血液透析治疗的患者中，这两种形式的对甲酚水平也明显高于接受血液透析滤过治疗的患者。单变量cox比例风险分析显示游离对甲酚浓度与心血管疾病（CVD）明显相关。许多游离对甲酚浓度高的患者发生了新的致命或非致命心血管事件。除此之外，还发现对甲酚可抑制细胞增殖。它抑制培养的内皮细胞增殖 26%，而不影响细胞活力。此外，浓度为 10、25 和 50 μg/ml 的对甲酚治疗分别使内皮伤口修复减少了 19%、28% 和 40% 1,2。