O-desmethyl Galantamine is an active metabolite of the alkaloid galantamine .1 It is formed from galantamine by the cytochrome P450 (CYP) isoform CYP2D6.2 O-desmethyl Galantamine inhibits erythrocyte and brain acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE; IC50s = 0.12, 0.5, and 24 ?M, respectively). It also prevents decreases in the viability of SH-SY5Y cells induced by hydrogen peroxide, amyloid-β (25-35) , or cobalt chloride when used at concentrations ranging from 6.25 to 100 ?M.3
1.Maláková, J., Nobilis, M., Svoboda, Z., et al.High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samplesJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.853(1-2)265-274(2007) 2.Bachus, R., Bickel, U., Thomsen, T., et al.The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6Pharmacogenetics9(6)661-668(1999) 3.Zhu, Y.-Y., Li, X., Yu, H.-Y., et al.Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activitiesArch. Pharm. Res.38(5)604-613(2015)