GlpBio

NS-3-008 hydrochloride

目录号: GC61140纯度: >99.50%
NS-3-008hydrochloride是一种口服活性的G0s2转录抑制剂，IC50为2.25μM。NS-3-008hydrochloride可用于慢性肾脏疾病。
NS-3-008 hydrochloride
Cas No.: 1172854-54-4
规格价格库存数量操作
5mg¥720.00现货
1
10mg¥1,080.00现货
1
50mg¥3,240.00现货
1
10mM (in 1mL DMSO)¥792.00现货
1
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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

产品描述 Description

NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease[1].

NS-3-008 binds to Hsd17b4; knockdown of Hsd17b4 decreased G0s2 mRNA levels, whereas overexpression of Hsd17b4 induced G0s2 mRNA expression. The inhibitory effects of NS-3-008 are blocked by knockdown of Hsd17b4 or deletion of the Stat5 binding site in the G0s2 promoter. NS-3-008 decreases the nuclear phosphorylation of Stat5[1].

NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1].

[1]. Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1172854-54-4
SMILES
N=C(NCC1=CC=CC=C1)NCCCCCC.Cl
分子式
C14H24ClN3
分子量
269.81 g/mol
溶解性
DMSO: 125 mg/mL (463.29 mM); Water: 125 mg/mL (463.29 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol