Nordeoxycholic Acid, a hydrophobic bile acid metabolite, acts as a model compound in LC-MS/MS measurement for the related metabolite detection [1]. Nordeoxycholic acid forms three kinds of host frameworks, M1, M2, and M3, with channels where aliphatic alcohols are accommodated [2]. Nordeoxycholic acid can be used as an indicator to assist in the diagnosis of calcific aortic valve stenosis (CAVS) [3]. Nordeoxycholic acid acts a diagnostic biomarker for acute pancreatitis (AP)[4].
In vivo, Nordeoxycholic Acid treatment via oral gavage at a dose of 125mg/kg/day for 5 days induced extensive hepatic inflammation and live damage in mice[5].
References:
[1] Cao Y, Niu X, Li W, et al. Structural identification of in vitro metabolites for 23-nordeoxycholic acid by structural analogue matching[J]. Analytical Methods, 2023, 15(21): 2588-2598..
[2] Kato K, Aoki Y, Sugahara M, et al. Interpretation of enantioresolution in nordeoxycholic acid channels based on the four‐location model[J]. Chirality: The Pharmacological, Biological, and Chemical Consequences of Molecular Asymmetry, 2003, 15(1): 53-59.
[3] Atefi N, Surendran A, Raabe M, et al. Role of Bile Acids in Calcific Aortic Valve Stenosis[J]. Circulation, 2021, 144(Suppl_1): A9316-A9316.
[4] Liu X, Yu J, Liu J, et al. Norcholic Acid Promotes M1 Macrophage Polarization in Acute Pancreatitis by Activating the Wnt/β-Catenin Pathway[J]. Frontiers in Bioscience-Landmark, 2025, 30(6): 39259.
[5] Guo W, Zhong W, He L, et al. Reversal of hepatic accumulation of nordeoxycholic acid underlines the beneficial effects of cholestyramine on alcohol-associated liver disease in mice[J]. Hepatology Communications, 2024, 8(8): e0507.
Nordeoxycholic Acid是一种疏水性胆汁酸代谢物，可作为LC-MS/MS测定中相关代谢物检测的模型化合物[1]。Nordeoxycholic Acid可形成三种主-客体结构框架（M1、M2和M3），其中的通道能够容纳脂肪醇[2]。Nordeoxycholic Acid可作为辅助诊断钙化性主动脉瓣狭窄（CAVS）的指标[3]。Nordeoxycholic Acid是急性胰腺炎（AP）的诊断性生物标志物[4]。
在体内，以每日125mg/kg的剂量通过口服灌胃给予Nordeoxycholic Acid，持续5天，可诱导小鼠出现广泛的肝脏炎症和肝损伤[5]。