Nitrofurantoin-13C3 is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1 In vivo, nitrofurantoin (25-100 mg/kg) reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as calculi and abscess formation, in a rat model of P. vulgaris urinary tract infection.2 Formulations containing nitrofurantoin have been used to treat urinary tract infections.
1.Rocha, H., Da Silva Teles, E., and Barros, M.Site of action of nitrofurantoin in experimental urinary tract infectionAppl. Microbiol.18(4)547-549(1969) 2.Hossack, D.J.N.Proteus vulgaris urinary tract infections in rats; treatment with nitrofuran derivativesBr. J. Pharmacol. Chemother.19(2)306-312(1962)