Nitrendipine-d5 is the deuterium labeled Nitrendipine. Nitrendipine (BAY-E-5009), an analogue of Nifedipine (calcium channel blocker with vasodilator action. Nitrendipine has antipertensive effect[1][2][3][4].
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Bellemann, P., et al., [3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes. Arzneimittelforschung, 1981. 31(12): p. 2064-7.
[3]. S Kazda, et al. Diuretic effect of nitrendipine contributes to its antipertensive efficacy: a review. J Cardiovasc Pharmacol. 1988;12 Suppl 4:S1-5.
[4]. M Bursztyn, et al. Nitrendipine improves glucose tolerance and deoxyglucose uptake in pertensive rats. pertension. 1994 Jun;23(6 Pt 2):1051-3.
[5]. He-Hui Xie, et al. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in pertensive rats. J pertens. 2005 Jan;23(1):193-201.