N-Nitrosodietlamine-d10 is the deuterium labeled N-Nitrosodietlamine[1]. N-Nitrosodietlamine (Dietlnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodietlamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodietlamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodietlamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.