N-metl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model. N-metl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity[1].
N-metl-N-dithiocarboxyglucamine (1.1 mM/kg；腹腔注射；单剂量) 可显著诱导 Cd 从粪便排泄。而增加处理次数到每周 7 次后，导致小鼠全身 Cd 负荷减少了 50% 以上[1]。
[1]. Gale GR, et al. Effects of sodium N-metl-N-dithiocarboxyglucamine on cadmium distribution and excretion. Life Sci. 1984 Dec 17;35(25):2571-8.