MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A)

目录号: GC32730纯度: >98.00%同义词: MTDIA; Methylthio-DADMe-Immucillin A

An MTAP inhibitor

MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A)

Cas No.: 653592-04-2

规格	价格	库存	数量
5mg	¥896.00	现货	1
10mg	¥1,523.00	现货	1
25mg	¥3,045.00	现货	1
10mM (in 1mL DMSO)	¥986.00	现货	1

电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

MT-DADMe-ImmA is an inhibitor of 5'-methylthioadenosine phosphorylase (MTAP; K_i = 1.7 nM).¹ It increases levels of MTA , a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 ?M.² MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.

1.Evans, G.B., Furneaux, R.H., Lenz, D.H., et al.Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylaseJ. Med. Chem.48(14)4679-4689(2005) 2.Basu, I., Cordovano, G., Das, I., et al.A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancersJ. Biol. Chem.282(29)21477-21486(2007)

实验参考方法 Experimental Reference Method

Cell experiment:

Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 104 cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100 pM to 100 μM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20 μM). IC50 is determined with the assay data[2].

Animal experiment:

Mice: Tumors were established in mice for 5 days prior to oral or intraperitoneal treatments with MT-DADMe-ImmA. Mice are treated with oral dose of 21 mg/kg or an intraperitoneal dose of 5 mg/kg/day MT-DADMe-ImmA[2].

References:

[1]. Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89.
[2]. Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号

653592-04-2

同义词

MTDIA; Methylthio-DADMe-Immucillin A

SMILES

O[C@H]1CN(CC2=CNC3=C(N)N=CN=C32)C[C@@H]1CSC

分子式

C₁₃H₁₉N₅OS

分子量

293.39 g/mol

溶解性

DMSO : ≥ 33.33 mg/mL (113.60 mM)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

质量 (Mass)

体积 (Volume)

浓度 (Concentration)

分子量 (MW)

g/mol