IC50: 14 nM (MALT1)[1]
MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1].
MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM[1].
[1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313.