MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1].
MK-8189 (0.25-0.75 mg/kg; po) 以剂量依赖的方式减弱大鼠的运动活动。
| Animal Model: | Male Wistar-Hannover rats[1] |
| Dosage: | 0.25, 0.5, and 0.75 mg/kg |
| Administration: | Oral administration |
| Result: | Improved identification ability relative to the vector handling animal. |
[1]. Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66(2):1157-1171.