MK-0493 hydrochloride

目录号: GC72893纯度: >98.00%
MK-0493 hydrochloride是一种强效、口服活性和选择性的黑皮质素受体4(MC4R)激动剂,显示出能量摄入的显著减少。

MK-0493 hydrochloride
Cas No.: 455957-71-8
规格价格库存数量操作
1 mg¥1,755.00现货
1
5 mg¥3,870.00现货
1

文献被引

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产品描述 Description

MK-0493 drochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

References:
[1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66.
[2]. Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21(2):311-5.
[3]. Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2330-4.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
455957-71-8
分子式
C30H39Cl2F2N3O2
分子量
582.55 g/mol
溶解性
DMSO : 200 mg/mL (343.32 mM; Need ultrasonic)
保存条件
4°C, sealed storage, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol