Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.
Militarine remarkably decreases in IL-6, TNF-α, cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) mRNA levels, phospho-IκB kinase β/IκB kinase β (p-IKKβ/IKKβ), phospho-nuclear factor of kappa B p65/nuclear factor of kappa B p65 (p-NF-κBp65/NF-κBp65) and COX-2 proteins, concomitant with a significant increase of expression of inhibitor of NF-κB (IκBα) protein in PM 2.5-exposed human lung alveolar epithelial A549 cells.[2]
Militarine promotes rehabilitation of white matter, and increases levels of myelin basic protein (MBP), also markedly suppresses loss of CNPase-positive oligodendrocytes in rats with chronic cerebral hypoperfusion.[1]
[1] Wang Y, et al. Yao Xue Xue Bao. 2016 May;51(5):738-42. [2] Cheng W, et al. Eur J Pharmacol. 2021 Apr 5;896:173931.
















