Midodrine-d6 is intended for use as an internal standard for the quantification of midodrine by GC- or LC-MS. Midodrine is a prodrug form of the α1-adrenergic receptor (α1-AR) agonist desglymidodrine.1 It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats.2 Formulations containing midodrine have been used in the treatment of orthostatic hypotension.
1.McClellan, K.J., Wiseman, L.R., and Wilde, M.I.Midodrine. A review of its therapeutic use in the management of orthostatic hypotensionDrugs Aging12(1)76-86(1998) 2.Dabasaki, T., Shimojo, M., Ishikawa, H., et al.Anti-hypotensive effects of M6434, an orally active α1-adrenoceptor agonist, in ratsJpn. J. Pharmacol.59(2)145-150(1992)