Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3 It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2 Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12 as a coenzyme.3 A deficiency in vitamin B12 leads to a build-up of methylmalonyl-CoA.4
Reference
1. Anthony, C. How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathway Sci. Prog. 94(Pt 2), 109-137 (2011).
2. Tabita, F.R. The hydroxypropionate pathway of CO2 fixation: Fait accompli Proc. Natl. Acad. Sci. U.S.A. 106(50), 21015-21016 (2009).
3. Medicine, I.o. Vitamin B12 Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline 306-356 (1998).
4. Cardinale, G.J., Carty, T.J., and Abeles, R.H. Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B12 deficiency, on fatty acid synthesis J. Biol. Chem. 245(15), 3771-3775 (1970).