GlpBio

E3 ligase Ligand-Linker Conjugates 18

目录号: GC30105纯度: >98.50%同义词: Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18
A PROTAC building block
E3 ligase Ligand-Linker Conjugates 18
Cas No.: 2098488-36-7
规格价格库存数量操作
100mg¥3,150.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.1 It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.

1.Schiedel, M., Herp, D., Hammelmann, S., et al.Chemically induced degradation of Sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)J. Med. Chem.61(2)482-491(2018)

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
2098488-36-7
同义词
Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18
SMILES
O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN=[N+]=[N-])=O
分子式
C19H20N6O6
分子量
428.4 g/mol
溶解性
DMSO : ≥ 41 mg/mL (95.70 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol