Methylchloroisothiazolinone/Methylisothiazolinone Mixture

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.^1,2 It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively.² MCIT/MIT can elicit contact sensitization.³ Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products.

1.Frenzel, E., Schmidt, S., Niederweis, M., et al.Importance of porins for biocide efficacy against Mycobacterium smegmatisApplied and Environmental Microbiology77(9)3068-3073(2011) 2.Lundov, M.D., Johansen, J.D., Zachariae, C., et al.Low-level efficacy of cosmetic preservativesInt. J. Cosmet. Sci.33(2)190-196(2011) 3.Scherrer, M.A.R., and Rocha, V.B.Increasing trend of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI)An. Bras. Dermatol.89(3)527-528(2014)