GlpBio

Menaquinone-7 (Vitamin K2-7)

目录号: GC32498纯度: >98.00%同义词: 维生素K2(35),Vitamin K2-7; Vitamin K2(35); Vitamin MK-7
Menaquinone-7 (Vitamin K2-7)是维生素K系列中非常有价值的一员，除了对凝血有积极作用外，还对预防骨质疏松症和心血管疾病有显著作用。
Menaquinone-7 (Vitamin K2-7)
Cas No.: 2124-57-4
规格价格库存数量操作
5mg¥700.00现货
1
10mg¥980.00现货
1
50mg¥2,030.00现货
1
100mg¥3,430.00现货
1
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文献被引

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产品描述 Description

Menaquinone-7 (Vitamin K2-7), a highly valuable member of the vitamin K series, has significant effects on preventing osteoporosis and cardiovascular disease besides its positive effects on blood coagulation [1].

Menaquinone-7 (10 µM) treated MC3T3E1 cells for 24, 48, 96 and 240 h, no statistical differences at 24, 48 and 96 h, the growth of MK-7 treated cells was significantly suppressed at 240 h. Menaquinone-7 increased osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells [2]. After 24 h of Menaquinone-7 administration, genes upregulated by Menaquinone-7 included tenascin C and BMP2. Genes downregulated by Menaquinone-7 administration included biglycan and butyrophilin [3]. Menaquinone-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats [4]. Menaquinone-7 (10 µM) promotes osteoblast maturation thereby increasing osteogenic differentiation [5].

Menaquinone-7 increased The bone formation marker osteocalcin (OC), which is the bone formation marker [6]. Menaquinone-7 (200 mg/1,000 g fed with diets) supplementation decreases the bone resorption index and increases the bone formation index, balancing bone metabolism, and is considered to prevent bone loss [6].

References:
[1]. Mahdinia E, Demirci A, Berenjian A. Production and application of menaquinone-7 (vitamin K2): a new perspective[J]. World Journal of Microbiology and Biotechnology, 2017, 33(1): 1-7.
[2]. Katsuyama H, Otsuki T, Tomita M, et al. Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells[J]. International journal of molecular medicine, 2005, 15(2): 231-236.
[3]. Katsuyama H, Saijoh K, Otsuki T, et al. Menaquinone-7 regulates gene expression in osteoblastic MC3T3E1 cells[J]. International journal of molecular medicine, 2007, 19(2): 279-284.
[4]. Ehara Y, Takahashi H, Hanahisa Y, et al. Effect of vitamin K2 (menaquinone-7) on bone metabolism in the femoral-metaphyseal tissues of normal and skeletal-unloaded rats: enhancement with zinc[J]. Research in experimental medicine, 1996, 196(1): 171-178.
[5]. Akbulut A C, Wasilewski G B, Rapp N, et al. Menaquinone-7 supplementation improves osteogenesis in pluripotent stem cell derived mesenchymal stem cells[J]. Frontiers in cell and developmental biology, 2021, 8: 618760.
[6]. Brown J P, Malaval L, Chapuy M C, et al. Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis[J]. The Lancet, 1984, 323(8386): 1091-1093.

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

Primary astrocytes

Preparation Method

The astrocytes were divided into the pretreatment group and no pretreatment group. In the pretreatment group, the astrocytes were pretreated for 30 h with Menaquinone-7 concentrations (10, 50, 100, and 150 µM) with 10% FBS in DMEM/F12. They were then maintained under either normoxic (5% CO2 /95% air, 37°C) or hypoxic (5% CO2 /95% N2, 37°C) conditions for different time intervals. The culture medium was changed to glucose-free Dulbecco's Modified Eagle's Medium without FBS before incubating the astrocytes under hypoxic onditions. Hypoxia was induced by incubating the astrocytes using the hypoxic workstation.

Reaction Conditions

10, 50, 100, and 150 µM for 30 h

Applications

Pretreatment with Menaquinone-7 did not cause these apparent morphological alterations in these astrocytes. the morphological alterations in astrocytes pretreated with Menaquinone-7 were reduced and the number of adherent astrocytes significantly increased under hypoxic conditions.
Animal experiment [2]:

Animal models

4-week-old C57BL/6J male mice

Preparation Method

The AIN-93G diets consisted of a normal diet (N), normal diet + vitamin K1 (N-K1), normal diet + Menaquinone-7 (N-K2), 45% high-fat diet (HF), 45% high-fat diet + vitamin K1 (HF-K1), and a 45% high-fat diet + Menaquinone-7 (HF-K2). The vitamin K1 and Menaquinone-7 contents were 200 mg/1,000 g, and the diet was provided in pellet form. Food intake amount was measured every other day. Body weight was measured once a week, and the food efficiency ratio (FER) was calculated by dividing the increased body weight from day1 to the final day by the food intake amount during the experiment period.

Dosage form

200 mg/1,000 g fed with AIN-93G diets

Applications

Osteocalcin (OC) level of HF groups which were supplemented with vitamin K1 or Menaquinone-7, was higher than that in the HF diet-only group , type I collagen Ctelopeptide (CTx) was lower in the vitamin K-supplemented HF groups than the HF diet-only group.

References:

[1]: Yang R Y, Pan J Y, Chen Y, et al. Menaquinone-7 protects astrocytes by regulating mitochondrial function and inflammatory response under hypoxic conditions[J]. Eur. Rev. Med. Pharmacol. Sci, 2020, 24: 10181-10193.
[2]: Kim M, Na W, Sohn C. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice[J]. Journal of clinical biochemistry and nutrition, 2013: 13-25.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2124-57-4
同义词
维生素K2(35),Vitamin K2-7; Vitamin K2(35); Vitamin MK-7
SMILES
O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C2=C1C=CC=C2)=O
分子式
C46H64O2
分子量
649 g/mol
溶解性
DMSO : 5 mg/mL (7.70 mM);Water : < 0.1 mg/mL (insoluble)
保存条件
Store at -20°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol