GlpBio

MC3138

目录号: GC73903纯度: >99.00%
MC3138是一种选择性SIRT5激活剂。
MC3138
Cas No.: 1844889-12-8
规格价格库存数量操作
5 mg¥990.00现货
1
10 mg¥1,530.00现货
1
25 mg¥3,060.00现货
1
50 mg¥4,950.00现货
1
10mM (in 1mL DMSO)¥1,089.00现货
1
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文献被引

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    641, 529–536 (2025)
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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine significantly inhibits tumor growth in mice.

MC3138 (10 μM, 24 h) decreases lysine acetylation of the GOT1 protein and inhibits its enzymatic activity in PDAC cells[1].

References:
[1]. Hu T, et al. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1844889-12-8
分子式
C25H25NO6
分子量
435.47 g/mol
溶解性
DMSO : 200 mg/mL (459.27 mM; Need ultrasonic)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol