m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity. It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 µg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors. MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes.
m-Iodobenzylguanidine (hemisulfate)
目录号: GC44197纯度: >99.50%同义词: 硫酸碘苄胍EP标准品,MIBG sulfate
A norepinephrine analogue with anticancer activity
Cas No.: 87862-25-7
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥248.00 | 现货 | 1 | |
| 5mg | ¥560.00 | 现货 | 1 | |
| 10mg | ¥805.00 | 现货 | 1 | |
| 25mg | ¥1,484.00 | 现货 | 1 | |
| 50mg | ¥2,310.00 | 现货 | 1 | |
| 100mg | ¥3,640.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥399.00 | 现货 | 1 |
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Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
产品描述 Description
产品文档 Product Documents
Purity:>99.50%
化学性质Chemical Properties
CAS 号
87862-25-7
同义词
硫酸碘苄胍EP标准品,MIBG sulfate
SMILES
IC1=CC=CC(CNC(N)=N)=C1.O=S(O)(O)=O
分子式
C8H10IN3•1/2H2SO4
分子量
324.1 g/mol
溶解性
DMSO: 2 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol