GlpBio

LSN2463359

目录号: GC18309纯度: >98%同义词: N-异丙基-5-(吡啶-4-基乙炔基)吡啶酰胺
COASDSData Sheet
A brain penetrant positive allosteric modulator of the mGluR5
LSN2463359
Cas No.: 1401031-52-4
规格价格库存数量操作
5mg¥1,540.00现货
1
10mg¥2,834.00现货
1
25mg¥6,345.00现货
1
50mg¥3,960.00现货
1
100mg¥5,940.00现货
1
10mM (in 1mL DMSO)¥980.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

LSN2463359 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5; EC50 = 24 nM). It is without effect at other mGluRs. LSN2463359 is brain penetrant and reverses learning deficits in a rat model of schizophrenia. Through its effects on mGluR5, LSN2463359 attenuates deficits in performance in operant behavior induced by SDZ-220581, an NMDA receptor antagonist, in rats. It also promotes wakefulness in animals.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
1401031-52-4
同义词
N-异丙基-5-(吡啶-4-基乙炔基)吡啶酰胺
化学名
N-(1-methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide
SMILES
O=C(NC(C)C)C(C=C1)=NC=C1C#CC2=CC=NC=C2
分子式
C16H15N3O
分子量
265.3 g/mol
溶解性
DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol