Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis.1 It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).
1.Yi, G., Deval, J., Fan, B., et al.Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvirAntimicrob. Agents Chemother.56(2)830-837(2012)