GlpBio

LL-K8-22

目录号: GC73219纯度: >99.00%
LL-K8-22是一种高效、选择性和耐用的CDK8-cyclin C双降解剂，其DC50值分别为2.52 μM和2.64 μM。
LL-K8-22
规格价格库存数量操作
1 mg¥1,485.00现货
1
5 mg¥3,690.00现货
1
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文献被引

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

LL-K8-22 is a potent, selective and durable CDK8-cyclin C dual degrader, with DC50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research.

LL-K8-22 (0-10 μM, 24 h) degrades the CDK8-cyclin C complex in a dose-dependent manner[1]. LL-K8-22 (0-20 μM, 4 days) suppresses tumor cell proliferation[1].LL-K8-22 (0-8 μM, 24 h) inhibits CDK8-cyclin C downstream signaling[1]. LL-K8-22 significantly downregulated EAPP (E2F family binding protein)[1].LL-K8-22 dose not affect CDK8 and CCNC mRNA levels[1].

References:
[1]. Wang M, et al. Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex. J Med Chem. 2023 Apr 13;66(7):4932-4951.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

分子式
C37H43N5O
分子量
573.77 g/mol
溶解性
DMSO : 125 mg/mL (217.86 mM; Need ultrasonic)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol