GlpBio

Lenalidomide-I

目录号: GC62147纯度: >98.50%同义词: 3-(4-碘-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
Lenalidomide-I 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。Lenalidomide-I 可通过 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC BET 降解剂 QCA570 。
Lenalidomide-I
Cas No.: 2207541-30-6
规格价格库存数量操作
100mg¥203.00现货
1
250mg¥351.00现货
1
500mg¥540.00现货
1
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产品描述 Description

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1].

Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
2207541-30-6
同义词
3-(4-碘-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
分子式
C13H11IN2O3
分子量
370.14 g/mol
溶解性
DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol