Ladostigil hydrochloride

目录号: GC69353纯度: >99.00%同义词: TV-3326 hydrochloride
Ladostigil (TV-3326) hydrochloride 是一种口服有效的胆碱酯酶 (cholinesterase) 和脑选择性单胺氧化酶 (MAO) 的双重抑制剂,抑制 MAO-B 和 AChE 的 IC50 值分别为 37.1 和 31.8 μM。Ladostigil hydrochloride 具有神经保护,抗氧化和抗炎的作用,可用于抑郁症和阿尔茨海默症的研究。

Ladostigil hydrochloride
Cas No.: 209394-18-3
规格价格库存数量操作
10mg¥7,200.00现货
1

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产品描述 Description

Ladostigil (TV-3326) drochloride is an orally active dual inhibitor of Inhibited brain MAO-A and B by more than 60%.
Reduced peranxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.

[1]. Denya I, et, al. Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease. Medchemcomm. 2018 Jan 16; 9(2):357-370.
[2]. Weinreb O, et, al. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr; 13(4): 483-94.
[3]. Weinstock M, et, al. Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression. J Neural Transm Suppl. 2006; (70):443-6.
[4]. Poltyrev T, et, al. Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the pothalamic-pituitary-adrenal axis in male and female prenatally stressed rats. Psychopharmacology (Berl). 2005 Aug;181(1): 118-25.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
209394-18-3
同义词
TV-3326 hydrochloride
分子式
C16H21ClN2O2
分子量
308.8 g/mol
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol