Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is effective at nanomolar concentrations.1,2 It is reported to control hypertension.3,4
1.Brittain, R.T., and Levy, G.P.A review of the animal pharmacology of labetalol, a combined α- and β-adrenoceptor-blocking drugBr. J. Clin. Pharmacol.3(4 suppl 3)681-684(1976) 2.Richards, D.A.Pharmacological effects of labetalol in manBr. J. Clin. Pharmacol.3(4 suppl 3)721-723(1976) 3.Owens, W.B.Blood pressure control in acute cerebrovascular diseaseJ. Clin. Hypertens. (Greenwich)13(3)205-211(2011) 4.Kernaghan, D., Duncan, A.C., and McKay, G.A.Hypertension in pregnancy: A review of therapeutic optionsObstet. Med.5(2)44-49(2012)