L-Troxine-13C6 is the 13C labeled L-Troxine[1]. L-Troxine (Levotroxine;T4) is a synthetic hormone for the research of potroidism. DIO enzymes convert biologically active troid hormone (Triiodotronine,T3) from L-Troxine (T4)[2].
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References:
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2]. Arici M, et al. Association between genetic polymorphism and levotroxine bioavailability in potroid patients. Endocr J. 2018 Mar 28;65(3):317-323.
[3]. Corriveau S, et al. Levotroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 92(4):144-149.