GlpBio

KB-0742 dihydrochloride

目录号: GC62392纯度: >99.50%
KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.
KB-0742 dihydrochloride
Cas No.: 2416874-75-2
规格价格库存数量操作
5 mg¥2,340.00现货
1
10 mg¥4,050.00现货
1
25 mg¥7,200.00现货
1
50 mg¥12,600.00现货
1
100 mg¥16,714.00现货
1
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文献被引

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产品描述 Description

KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.

KB-0742 rapidly downregulates nascent transcription, preferentially depleting short half-life transcripts and AR-driven oncogenic programs in 22Rv1 cells. [1]

KB-0742 is a remarkably selective CDK9 inhibitor that leads to global downregulation of nascent transcription and AR-driven prostate cancer gene expression programs and displays in vivo efficacy in CRPC- and AML-derived xenograft models.[1]

[1] André Richters, et al. Cell Chem Biol . 2021 Feb 18;28(2):134-147.e14.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
2416874-75-2
分子式
C16H27Cl2N5
分子量
360.33 g/mol
溶解性
Water : 100 mg/mL (277.52 mM; Need ultrasonic)|DMSO : 62.5 mg/mL (173.45 mM; Need ultrasonic)
保存条件
4°C, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol