JZP 430 is an inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 0.044 for the human enzyme).1 It is selective for ABHD6 over fatty acid amid hydrolase (FAAH) and monoacylglycerol lipase (MAGL) when used at a concentration of 2.5 ?M, ABHD12 at 1 ?M, as well as lysosomal acid lipase (LAL) and cannabinoid 1 (CB1) and CB2 receptors at 10 ?M.
1.Patel, J.Z., Nevalainen, T.J., Savinainen, J.R., et al.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitorsChemMedChem10(2)253-265(2015)