GlpBio

JH-X-119-01

目录号: GC63925纯度: >98.00%
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM.
JH-X-119-01
Cas No.: 2227368-54-7
规格价格库存数量操作
5 mg¥1,620.00现货
1
10 mg¥2,430.00现货
1
25 mg¥4,410.00现货
1
50 mg¥6,570.00现货
1
100 mg¥8,910.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM.

JH-X-119-01 is a highly efficient and selective covalent inhibitor of interleukin 1 (IL-1) receptor-associated kinase (IRAK) 1 and irreversibly labels IRAK1 at C302, showing moderate cell killing effects with EC50s ranging from 0.59 to 9.72 μM in a panel of WM cells, DLBCL cells, and lymphoma cells.[1]

[1] John M Hatcher, et al. ACS Med Chem Lett. 2020 Oct 9;11(11):2238-2243.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2227368-54-7
分子式
C25H20N6O3
分子量
452.46 g/mol
溶解性
DMSO : 250 mg/mL (552.54 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol