Isopimpinellin is a furanocoumarin that has been found in H. persicum and has diverse biological activities.1,2,3 It inhibits lipid peroxidation in a cell-free assay.1 Isopimpinellin (20 ?M) prevents histamine release from, and activation of NF-κB in, RBL-2H3 cells.2 It also decreases the secretion of TNF-α, IL-1β, and IL-4 from RBL-2H3 cells. Isopimpinellin prevents benzo[a]pyrene-DNA adduct formation in sensitivity to carcinogenesis (SENCAR) mice when administered at a dose of 70 mg/kg and reduces the number of papillomas initiated and promoted by 7,12-dimethylbenz[a]anthracene in SENCAR mice when administered at 30, 70, or 150 mg/kg.3
1.Souri, E., Farsam, H., Sarkheil, P., et al.Antioxidant activity of some furanocoumarins isolated from Heracleum persicumPharm. Biol.42(6)396-399(2004) 2.Li, D., and Wu, L.Coumarins from the roots of Angelica dahurica cause anti-allergic inflammationExp. Ther. Med.14(1)874-880(2017) 3.Kleiner, H.E., Vulimiri, S.V., Starost, M.F., et al.Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[α]anthracene in SENCAR miceCarcinogenesis23(10)1667-1675(2002)