GlpBio

Indolicidin

目录号: GC32207纯度: >99.00%
An antimicrobial peptide
Indolicidin
Cas No.: 140896-21-5
规格价格库存数量操作
500μg¥1,428.00现货
1
1mg¥2,321.00现货
1
5mg¥6,962.00现货
1
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文献被引

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产品描述 Description

Indolicidin is an antimicrobial peptide.1 It is active against multidrug-resistant isolates of enteroaggregative E. coli (MDR-EAEC; MICs = 32 ?M for all). Indolicidin is also active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 ?M, respectively) and reduces viral replication of HIV-1 in MT-2 cells when used at concentrations ranging from 67 to 100 ?g/ml.2,3 In vivo, indolicidin increases survival of MDR-EAEC-infected G. mellonella larvae.1

1.Vergis, J., Malik, S.S., Pathak, R., et al.Antimicrobial efficacy of indolicidin against multi-drug resistant enteroaggregative Escherichia coli in a Galleria mellonella modelFront. Microbiol.102723(2019) 2.Lee, D.G., Kim, H.K., Kim, S.A., et al.Fungicidal effect of indolicidin and its interaction with phospholipid membranesBiochem. Biophys. Res. Commun.305(2)305-310(2003) 3.Robinson, W.E., Jr., McDougall, B., Tran, D., et al.Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophilsJ. Leukoc. Biol.63(1)94-100(1998)

实验参考方法 Experimental Reference Method

Cell experiment:

The time course and dose dependence of indolicidin bactericidal activity are determined using Escherichia coli ML35 and Staphylococcus aureus 502A as test organisms. The assays are performed in 10 mM sodium phosphate buffer, pH 7.4, at 37°C. A 50 μg sample of indolicidin is dissolved in 50 pl of 0.1 M pyridine acetate, pH 6.5, and incubated with 5 μg of chymotrypsin for 15 h at 37°C. Digestion of the sample is confirmed by the disappearance of the indolicidin band on acid-urea PAGE. Following lyophilization, untreated and digested samples are tested for antibacterial activity in a agar diffusion assay against Escherichia coli using concentrations of peptide ranging from 10 to 300 μg/mL[1].

References:

[1]. Selsted ME, et al. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J Biol Chem. 1992 Mar 5;267(7):4292-5.
[2]. Falla TJ, et al. Mode of action of the antimicrobial peptide indolicidin. J Biol Chem. 1996 Aug 9;271(32):19298-303.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
140896-21-5
SMILES
Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2
分子式
C100H132N26O13
分子量
1906.28 g/mol
溶解性
Soluble in DMSO
保存条件
-20°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol