Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs).
Indazole-Cl (0.1 μM; 6 h) decreases intracellular ROS levels induced by hypoxia in vascular smooth muscle cells (VSMCs)[1].
Indazole-Cl (10 μM; 24 h) inhibits hypoxia-induced cyclooxygenase (COX)-2 transcriptional activity in VSMCs[1].
Indazole-Cl (1 μM; 24-72 h) prevents hypoxia-induced cellular migration and invasion in VSMCs[1].
References:
[1]. Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38.